FYI: Bias in endpoints in drug trials?

In 2012 there were over 16,000 journal articles mentioning breast cancer in the PubMed database. In the day to day bustle to keep up with the literature it may be difficult to give each article the critical appraisal it deserves!

The Annals of Oncology has released a new study,

F. E. Vera-Badillo, R. Shapiro, A. Ocana, E. Amir, and I. F. Tannock. Bias in reporting of end points of efficacy and toxicity in randomized, clinical trials for women with breast cancer Ann Oncol January 9, 2013. [doi:10.1093/annonc/mds636  ]

While not everyone will agree with the authors’ appraisals of the literature, the shortcomings identified may provide a helpful checklist of methods that may weaken the conclusions of some trials.

Older, but also of interest on the topic of bias (especially pages 61-63):
Sackett, D L (1979). “Bias in analytic research”. Journal of chronic diseases, 32 (1-2), p. 51.

Ooops, we just added another TWO articles to your “to read” list!  But maybe these will help thin the rest of the pile?

[Lynne M. Fox, Education Librarian]